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Antisynthetase syndrome

Names 

Anti-Jo1 syndrome
Antisynthetase syndrome
AS syndrome

Description

The exact mechanism of this disease is not known, but it is known that autoantibodies attack aminoacyl-tRNA synthetases.  The autoantibodies can form due to heredity or a viral infection.

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Prevalence

US Cases: ~3,200 - 28,800
Source: orphanet

Typical Age of onset

43 - 60

Symptoms

Easy or excessive bruising (purpura)
Rash - pinpoint-sized reddish-purple spots (petechiae) usually on the lower legs
Bleeding from the gums or noseBlood in urine or stools
Unusually heavy menstrual flow

Sources:  Mayo Clinic, Healthline