`

Primary Sclerosing Cholangitis

Names

Primary Sclerosing Cholangitis
PSC
Chronic obliterative cholangitis
Fibrosing cholangitis
Stenosing Cholangitis

Description

PSC is a rare progressive disorder of the liver which is characterized by inflammation, thickening, and abnormal formation of fibrous tissue within the passages that carry bile from the liver (bile ducts). Both bile ducts within the liver and outside the liver are affected.

Prevalence

The exact incidence and prevalence of this disorder is unknown. One estimate places the incidence at approximately 1 person per each 100,000 in the general population in the US and Europe. The disease affects males twice as often as females.

Typical Age of onset

Age at diagnosis is found to be 30-40 years.

Symptoms

  • Fatigue

  • Abdominal discomfort

  • Itching (pruritus)

  • Obstructive jaundice

  • Malaise

  • Nausea

  • Dark Urine

  • Light colored stools

  • Enlargement of the liver and spleen