Ankylosing spondylitis



Ankylosing spondylitis
Axial spondyloarthritis

Ankylosing spondylitis is an inflammatory disease that affects the spine and large joints. Over time, ankylosing spondylitis can cause some of the vertebrae in the spine to fuse leading to a less flexible spine that results in a hunched-forward posture. 


Cases in the US: 320,000  to 4,480,000


1. Cleveland Clinic
2. Arthritis and Rheumatism

Typical Age of onset

Median age at diagnosis: 23
Rarely diagnosed after age 40



  • Constant pain and stiffness in the low back, buttocks, and hips for more than three months
  • Often starts in sacroiliac joints, where the spine joins the pelvis in the lower back 
  • Bony fusion that may limit a person's ability to expand his or her chest when taking a deep breath 
  • Pain in ligaments and tendons
  • Pain and stiffness in the area behind or beneath the heel
  • Systemic systems may include fever, fatigue, loss of appetite, eye inflammation

Sources:  Mayo Clinic