Cicatricial pemphigoid


Cicatricial pemphigoid
Mucous membrane pemphigoid
Ocular pemphigoid
Scarring pemphigoid


Cicatricial pemphigoid is a rare autoimmune disease, discovered in 2002, that causes blistering of the mucous membranes. This blistering is due to autoantibodies binding to anchoring filaments of the epidermis.  A common mucous membrane that is affected is the conjunctiva of the eye.  Other areas that can be affected include the skin, nose, mouth, and genitals.


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Prevalence varies dependent on autoantibody
US cases: ~1,600
Source: Orphanet Journal of Rare Diseases

Typical Age of onset

60-70 years


  • Eye sensitivity
  • Conjunctivitis
  • Lesions that lead to scar tissue
  • Nutritional deficiencies and weight loss
  • Blisters
  • Nose bleeds
  • Pain passing urine
  • Adhesions causing narrowing of the vaginal opening