Pernicious anemia



Pernicious Anemia
Macrocystic Anemia
Megaloblastic Anemia


A condition in which the body cannot produce enough red blood cells due to a lack of vitamin B12. People with pernicious anemia cannot absorb enough B12 from food because of a lack of intrinsic factor--a protein made in the stomach--which leads to vitamin B12 deficiency.


0.1% in the general population and 1.9% in patients over the age of 60.  Pernicious anemia represents 20%-50% of the causes of vitamin B12 deficiencies in adults. 

Typical Age of onset



●      Fatigue

●      Shortness of breath

●      Dizziness

●      Cold hands and feet

●      Chest pain

●      Pale or yellow skin

●      Trouble with balance

●      Burning sensation in legs or feet which may worsen at night

●      Depression

●      Difficulty focusing