What's new in CAR-T therapy research?

Last year, we wrote about the use of CAR-T therapy to treat patients with various autoimmune diseases. Prior studies have shown promising results, although there remain significant side effects associated with the treatment.

The Calibr-Skaggs Institute for Innovative Medicines announced earlier this month that the FDA approved its study to investigate a switchable CAR-T therapy (sCAR-T) in those with autoimmune diseases. Traditional CAR-T therapy requires lymphodepletion, a chemotherapy procedure that removes existing immune cells, in order to allow the CAR-T cells to work effectively without overwhelming the immune system. This can lead to increased risks of infection and other serious side effects. The sCAR-T therapy is specifically designed to avoid the need for prior lymphodepletion. 

What makes sCAR-T therapy different is that it is accompanied by a "switch" biologic protein that can turn on or off the effect of the CAR-T cells. Previously, lymphodepletion was needed to prevent the body's existing immune cells from overwhelming the CAR-T cells. But if doctors can turn on or off the CAR-T cells as needed, then they can reduce the intensity of the body's immune reactions, thereby reducing the risk of overactivation or immune interference. Phase I of the study will soon begin recruiting patients with lupus, rheumatoid arthritis, myositis, and systemic sclerosis. 

In other news, the Autoimmune Registry is proud to announce a new partnership with Smart Patients, an online peer-to-peer support forum for patients and their families, which will allow us to extend our ability to help those impacted by autoimmune diseases by adding virtual social and emotional support. Patients and families affected by autoimmune diseases can join the Smart Patients autoimmune community at no charge to share, interact, and learn from each other in a safe and supportive environment. 

To support the Autoimmune Registry, please share our information with others who have autoimmune diseases. Donations are also greatly appreciated!