Retroperitoneal fibrosis
Evidence: Unconfirmed
Names
Retroperitoneal fibrosis
IgG4-related retroperitoneal fibrosis
Idiopathic Retroperitoneal Fibrosis
Ormond’s Disease
Description
Retroperitoneal fibrosis is a rare autoimmune disease inflammatory disorder in which abnormal formation of fiber-like tissue occurs behind the membrane that lines the cavity of the abdomen. This abnormal tissue growth often spreads to affect the tubes that carry urine from the kidney to the bladder, frequently causing blockage.
Immunoglobulin-G 4 (IgG4), the least common subtype of immunoglobulin G (a type of protein that forms antibodies) is believed to be involved. The mechanism of IgG4 diseases is still being researched.
Patient Groups
Bloggers
N/A
Prevalence
US cases: 4,500 [Uibu 2004]. Male-to-female ratio is 2:1 to 3:1.
Typical Age of onset
55-60
Symptoms
● Pain in lower back or abdomen
● Weight loss
● Fever
● Nausea
● Anemia
● Loss of appetite
● Jaundice
● Swelling of one leg
