Stiff person syndrome
Evidence: Antibody
Names
Stiff person syndrome
Stiff man syndrome
Morsch Woltman syndrome
Moersch-Woltman syndrome
Description
Stiff person syndrome (SPS) is a rare, progressive syndrome believed to be autoimmune in nature, though the cause is currently unknown. SPS is characterized by decreased inhibition of the central nervous system, which leads to greater muscle activity causing flares of severe stiffness and spasms, usually in the muscles of the trunk and limbs. Triggers include noise, touch, and emotional distress. SPS may result in disability, fractures due to severe muscle contractions, and abnormal posture. Comorbidities may include diabetes, thyroiditis, vitiligo, and pernicious anemia. There is no cure, but symptoms can be managed through treatment.
Patient Groups
Prevalence
US Cases: 320 based on unsubstantiated estimate of 1 per 1,000,000 [Nguyen 2019]
Typical Age of onset
Can occur at any age but usually develop between ages 30 and 60. Source: Baizabal-Carvallo and Alonso-Juarez (2019)
Symptoms
Aching, stiffness, or pain in the lower back or legs
Gait abnormalities
Intermittent painful muscle spasms in the trunk and limbs
Hunched posture
Anxiety
Weight loss
Feeling full quickly after eating
